Heat oven to 375 degrees. Prepare a loaf pan with nonstick cooking spray.
In a bowl, mix turkey, 1/2 cup ketchup, bread crumbs, 2 tsp Worcestershire, pepper, garlic, onion flakes and egg.
Press mixture into loaf pan.
Mix remaining 1/2 cup ketchup, 1 tsp Worcestershire and mustard to make sauce. Spread evenly over the top of meatloaf.